An open system for automatic home-cage behavioral analysis and its application to male and female mouse models of Huntington's disease
Treatment of RTT female mice with AAV9-MCO only improved apneas occurrence. Using a higher vector dose caused severe off target effects specifi to RTT mice. Post-mortem analysis revealed damaged liver with high CHOP levels and TUNEL expression. Off target mecp2 expression may have led to UPR activation and subsequent apoptosis. These contrasting results underscore the need for additional work to limit side effects.
Expression of pathogenic SCN9A mutations in the zebrafish: A model to study small fiber neuropathy
Interleukin 6 deficiency affects spontaneous activity of mice in age- and sex-dependent manner