Marlau Cage

PUBLICATIONS

Enriched housing reverses age-associated impairment of c...

Although tissue type plasminogen activator (tPA) and brain derived neurotrophic factor (BDNF) have been extensively described to influence brain outcomes in a number of disorders, their roles during physiological aging are poorly investigated. In the present study, we investigated whether maintenance of mice in different environmental conditions could influence age-associated changes in hippocampal tPA expression and BDNF maturation in relation with modifications of their cognitive performances. Our data indicate that maintenance in enriched housing led to a reversal of age-associated decrease in expression of hippocampal tPA. A subsequent increase in the level of mature BDNF and an improvement in emotional and spatial memories were observed. Taken together, these data suggest that the tPA–BDNF axis could play a critical role in the control of cognitive functions influenced both by the age and housing conditions.

2011-05-11

Environmental enrichment accelerates ocular dominance pl...

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0186999

2012-01-01

Behavioral effects of different enriched environments in...

Environmental enrichment is an experimental model in which rodents are housed in complex environments that favor lower levels of anxiety-like behavior. PNU-282987 (PNU) is a α7 nicotinic acetylcholine receptor agonist with beneficial effects on learning though its effects on anxiety are unclear.

2014-03-01

Optimal neuroprotection by erythropoietin requires eleva...

Optimal neuroprotection by erythropoietin requires elevated expression of its receptor in neurons

2009-03-02