Insights into paradoxical (REM) sleep homeostatic regulation in mice using an innovative automated sleep deprivation method
ONEIROS, a new miniature standalone device for recording sleep electrophysiology, physiology, temperatures and behavior in the lab and field
published : 12 January 2020
Ciproxifan 3 mg/kg has an enhancing effect on working memory (WM) after an acute sleep restriction, via a decrease of proactive interference sensitivity. The cognitive beneficial effect of ciproxifan in sleep-restricted mice is associated to specific prefrontal cortex area activation.
Experience of behavior on mice
Patients with Parkinson's disease (PD) display significant sleep disturbances and daytime sleepiness. Dopaminergic treatment dramatically improves PD motor symptoms, but its action on sleep remains controversial, suggesting a causal role of nondopaminergic lesions in these symptoms.