VigiePrimates

FEATURES

References

Impairment of context-adapted movement selection in a primate model of presymptomatic Parkinson's disease
Mathias Pessiglione, Dominique Guehl, Yves Agid, Etienne C. Hirsch, Jean Féger and Léon Tremblay Neurologie et Thérapeutique expérimentale (INSERM U289), Hôpital de la Salpétrière, Paris, France.

Application of PET Imaging and Locomotor Activity Using Video Image Analysis in the Clinical Staging of MPTP-Lesioned Monkeys
A.G. DiLella1, S.M. Krause2, C. Ryan2, E. Hostetler2, S.M. Sanabria2, C.L. Burns3, C. Johnson3, S.L. Motzel3, G.R. Seabrook1, G.G. (1. Dept. Neurosci., 2. Dept. Imaging Res., 3. Lab. Animal Resources, Merck & Co., West Point, PA, USA).

Neuroprotective effect of riluzole in a primate model of Parkinson's disease: behavioral and histological evidence.
Obinu MC, Reibaud M, Blanchard V, Moussaoui S, Imperato A. - Neurodegenerative Disease Program, Research Center of Paris, Aventis Pharma, S.A. Vitry sur Seine, France.

Assessment of motor behavior using a video system and a clinical rating scale in parkinsonian monkeys lesioned by MPTP.
Chassain C, Eschalier A, Durif F. - Unite INSERM EMI 9904, Faculte de Medecine et Pharmacie, place Henri-Dunand, 63003, Clermont-Ferrand, France.

The antioxidant ebselen prevents neurotoxicity and clinical symptoms in a primate model of Parkinson's disease.
Moussaoui S, Obinu MC, Daniel N, Reibaud M, Blanchard V, Imperato A. - Aventis Pharma, CNS Program, Centre de Recherche de Vitry-Alfortville (Building CRV8), France.

This system has already be used to patent compounds:
Combinations of riluzole and levodopa for the treatment of Parkinson's disease
www.pharmcast.com/.../Parkinson

Neuroprotective Effect of Riluzole in a Primate Model of Parkinson Disease :
Behavioral and Histological Evidence Author:, Maria C.Obinu, PhD, Michel Reibaud, PhD, Veronique Blanchard, PhD, Saliha Moussaoui, PhD, and Assunta Imperato, PhD, Movement Disorders, Volume:17, N°.1,2002, pp .13 -19

Assessment of motor Behavior by VigiePrimates compared to clinical rating scales in Parkinsonian monkeys intoxicated by MPTP Chassain, C.*; Eschalier, A.; Durif, F. XIV International Congress on Parkinson's Disease, 27 July - 1 August 2001, Helsinki, Finland

The antioxidant ebselen prevents neurotoxicity and clinical symptoms in a primate model of Parkinson's disease.
Author:Moussaoui S, Obinu MC, Daniel N, Reibaud M, Blanchard V, Imperato A., Exp Neurol, Volume:166 Issue:2, Page:235-45 Year:2000 Dec

"A new video/computer method to measure the amount of overall movement in experimental animals (two-dimensional object-difference method)"
Takao Hashimoto, Yuji Izawa, Hisashi Yokoyama, Takashi Kato, Tetsuji Moriizumi. Journal of Neuroscience methods 91 (1999) 115-122.