ZebraLab

PUBLICATIONS

Zebrafish Behavioral Profiling Links Drugs to Biological...

We report the development and application of a high-throughput, quantitative screen for drugs that alter the behavior of larval zebrafish. We found that the multidimensional nature of observed phenotypes enabled the hierarchical clustering of molecules according to shared behaviors.

2010-01-15

Fatty acid-rich volatile oil from Syagrus coronata seeds...

http://www.sciencedirect.com/science/article/pii/S088557651730125X

2017-05-31

Vitamin E deficiency during embryogenesis in zebrafish c...

http://www.sciencedirect.com/science/article/pii/S0891584917306457

2017-06-20

Physiological role of amyloid precursor protein during n...

https://gupea.ub.gu.se/bitstream/2077/51893/1/gupea_2077_51893_1.pdf

2017-05-27

Evaluation of the sensitivity spectrum of a video tracki...

https://link.springer.com/article/10.1007/s11356-017-9262-4

2017-05-23

Transgenerational endocrine disruption and neurotoxicity...

http://www.sciencedirect.com/science/article/pii/S0269749117304268

2017-06-22

Light-Dependent Regulation of Sleep and Wake States by P...

http://www.cell.com/neuron/fulltext/S0896-6273(17)30499-3

2017-06-22

Left Habenular Activity Attenuates Fear Responses in Lar...

http://www.sciencedirect.com/science/article/pii/S0960982217307194

2017-07-14

Cortisol elevation post-hatch affects behavioural perfor...

http://www.sciencedirect.com/science/article/pii/S0016648017304975

2017-07-13

Measuring drug absorption improves interpretation of beh...

http://www.sciencedirect.com/science/article/pii/S1056871917301028

2017-07-13

Calpain inhibition is protective in Machado-Joseph disea...

Maxinne Watchon, Kristy C. Yuan, Nick Mackovski, Adam J. Svahn, Nicholas J. Cole, Claire Goldsbury, Silke Rinkwitz, Thomas S. Becker, Garth A. Nicholson and Angela S. Laird

2017-07-07

Toxicant induced behavioural aberrations in larval zebra...

http://www.sciencedirect.com/science/article/pii/S0378427417301984

2017-05-18

Kinetics of glucocorticoid exposure in developing zebraf...

http://www.sciencedirect.com/science/article/pii/S0045653517307634

2017-05-12

Optopharmacology with Zebrabox

OptoGluNAM4.1, a Photoswitchable Allosteric Antagonist for Real-Time Control of mGlu4 Receptor Activity.

2016-08-18

Distinct roles of neuroepithelial-like and radial glia-l...

http://dev.biologists.org/content/early/2017/03/09/dev.144907

2017-03-20

Toxicological and behavioral responses as a tool to asse...

http://www.sciencedirect.com/science/article/pii/S0045653517303831

2017-03-03

Effects of Dechlorane Plus exposure on axonal growth, mu...

http://www.sciencedirect.com/science/article/pii/S0269749116318917

2017-03-11

Dopaminergic control of anxiety in young and aged zebraf...

http://www.sciencedirect.com/science/article/pii/S009130571630212X

2017-04-10

Performance Study of TiO2-Au Photoelectric Nanocomposite...

http://www.jim.org.cn/EN/10.15541/jim20160458

2017-04-20

Effects of ibuprofen, diclofenac and paracetamol on hatc...

http://www.sciencedirect.com/science/article/pii/S0045653517307579

2017-05-10

Zebrafish embryo toxicity of 15 chlorinated, brominated,...

http://www.sciencedirect.com/science/article/pii/S1001074217301158

2017-05-11

Occurrence and ecotoxicological effects of free, conjuga...

http://pubs.acs.org/doi/abs/10.1021/acs.est.7b01231?journalCode=esthag

2017-05-09

Long-term exposure to elevated carbon dioxide does not a...

https://link.springer.com/article/10.1007/s00265-017-2337-x

2017-07-05

Endocrine, teratogenic and neurotoxic effects of cyanoba...

http://www.sciencedirect.com/science/article/pii/S0045653514009370

2017-07-27

Venlafaxine in embryos stimulates neurogenesis and disru...

http://pubs.acs.org/doi/abs/10.1021/acs.est.7b04099

2017-10-11

Inhibitors of nicotinamide phosphoribosyltransferase (NA...

https://academic.oup.com/toxsci/article-abstract/4372457/Inhibitors-of-nicotinamide

2017-10-09

Regulation of zebrafish (Danio rerio) locomotor behavior...

http://www.sciencedirect.com/science/article/pii/S0269749117316329

2017-10-07

Endocrine disruptors affect larval zebrafish behavior: T...

http://www.sciencedirect.com/science/article/pii/S0166445X17302801

2017-10-06

Characterization of the first knock-out aldh7a1 zebrafis...

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0186645

2017-10-20

Comparative developmental toxicity of a comprehensive su...

https://link.springer.com/article/10.1007/s00204-017-2068-9

2017-11-01

Mechanisms underlying melatonin-mediated prevention of f...

Jingjing Han, Cheng Ji, Yichen Guo, Rui Yan, Ting Hong, Yuanyan Dou, Yan An, Shasha Tao, Fenju Qin, Jihua Nie, Chen Ji, Han Wang, Jian Tong, Wei Xiao & Jie Zhang

2017-11-16

A Novel Experimental and Modelling Strategy for Nanopart...

http://www.mdpi.com/1660-4601/14/11/1348/htm

2017-11-06

Ecotoxicity of the insensitive munitions compound 3-nitr...

http://www.sciencedirect.com/science/article/pii/S0304389417307422

2017-09-28

Alterations of larval photo-dependent swimming responses...

http://www.sciencedirect.com/science/article/pii/S0147651317305936

2017-09-19

The Power of Zebrafish in Personalised Medicine

https://link.springer.com/chapter/10.1007/978-3-319-60733-7_10

2017-08-25

Effects of copper oxide nanoparticles and copper ions to...

http://www.sciencedirect.com/science/article/pii/S0887233317302266

2017-08-15

Analysis of neurobehavioural data by chemometric methods...

http://www.sciencedirect.com/science/article/pii/S0147651317305092

2017-08-09

Inhibition of glutamate decarboxylase (GAD) by ethyl ket...

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5543107/

2017-08-03

No effect of elevated carbon dioxide on reproductive beh...

https://academic.oup.com/beheco/article-abstract/doi/10.1093/beheco/arx112/4097644/No-effect-of-elevated-carbon-dioxide-on?redirectedFrom=fulltext

2017-08-30

Tris(1,3-dichloro-2-propyl) Disrupts Axonal Growth, Chol...

http://www.sciencedirect.com/science/article/pii/S0166445X17302412

2017-09-05

Comparison of cannabinoids with known analgesics using a...

http://www.sciencedirect.com/science/article/pii/S0166432817310239

2017-09-19

Upregulation of autophagy-related gene 5 protects dopami...

http://www.jbc.org/content/early/2017/09/19/jbc.M116.764795.full.pdf

2017-09-19

A Brain-Derived Neurotrophic Factor Mimetic Is Sufficien...

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595969/

2017-09-12

Use of Gammarus fossarum (Amphipoda) embryo for toxicity...

http://onlinelibrary.wiley.com/doi/10.1002/etc.3779/full

2017-03-07

Oxidative stress-mediated developmental toxicity induced...

http://onlinelibrary.wiley.com/doi/10.1002/jat.3432/full

2017-02-04

Antinociceptive effects of buprenorphine in zebrafish la...

Keywords Buprenorphine; Cyclooxygenase-2; Nociception; Pain; Zebrafish larvae

2014-03-01

Rest mutant zebrafish swim erratically and display atypi...

Highlights • Adult rest mutants engage in erratic swimming and display atypical spatial preferences. • rest mutant larvae are hypoactive when compared to sibling controls. • Adult rest mutant males but not females show diminished reproductive success.

2015-04-01

Zebrafish embryotoxicity test for developmental (neuro)t...

Highlights • The zebrafish embryotoxicity test (ZET) was applied using integrated multiple endpoints. • Morphology, motor activity, histopathology, kinetics and gene expression were studied. • A series of anti-epileptic drugs showed specific sensitivity for each endpoint. • This test strategy may contribute to elucidate the mode of action for developmental toxicity in ZET. • This test strategy may contribute to better define the applicability domain of the ZET.

2015-04-01

Quantitative Cross-Species Extrapolation between Humans...

Fish are an important model for the pharmacological and toxicological characterization of human pharmaceuticals in drug discovery, drug safety assessment and environmental toxicology. However, do fish respond to pharmaceuticals as humans do? To address this question, we provide a novel quantitative cross-species extrapolation approach (qCSE) ...

2014-10-22

Zebrafish embryotoxicity test for developmental (neuro)

HIGHLIGHTS - The zebrafish embryotoxicity test (ZET) was applied using integrated multiple endpoints - Morphology, motor activity, histopathology, kinetics and gene expression were studied - A series of anti-epileptic drugs showed specific sensitivity for each endpoint - This test strategy may contribute to elucidate the mode of action for developmental toxicity in ZET - This test strategy may contribute to better define the applicability domain of the ZET

2014-03-15

Measuring changes in locomotor activity of freshwater pr...

As the population grows, so does the drive for urbanization. Urbanization and the resulting anthropogenic activities have an impact on the quality of nearby water resources. Puerto Rico’s population density is one of the highest in the world. We seek to develop a protocol to measure how Puerto Rico´s high level of urban development has impacted the behavior and nervous system function of river fauna. We have started by recording movement trajectory and velocity of freshwater prawn larvae during five consecutive periods of 10-minutes light/dark cycles, using ViewPoint´s Zebrabox.

2014-04-01

Evaluating Complex Mixtures in the Zebrafish Embryo by R...

http://www.mdpi.com/1422-0067/18/3/539/htm

2017-03-07

Expression and functions of ASIC1 in the zebrafish retin...

Highlights • Both asic1 mRNA and protein expressions were detected in the adult zebrafish retina. • Acidosis-induced currents in the isolated retinal ganglion cells (RGCs) were recorded using whole cell patch clamping. • Blockade of ASICs channel significantly reduced the locomotion of larval zebrafish in response to light exposure.

2014-12-01

Abnormal differentiation of dopaminergic neurons in zebr...

Highlights • Zebrafish trpm7 mutant larvae exhibit dopamine-responsive behavioral deficits. • In such larvae, dopaminergic neurons express DAT but many lack expression of TH. • trpm7 mutant larvae are hyper-sensitive to a toxin of dopaminergic neurons, MPP+. • We show that SH-SY5Y cells, which are dopaminergic, depend on TRPM7 for survival. • How Trpm7 contributes to function and viability of dopaminergic neurons is unknown.

2010-01-01

Hippocampal Memory Traces Are Differentially Modulated b...

Memory traces are believed to be ensembles of cells used to store memories. To visualize memory traces, we created a transgenic line that allows for the comparison between cells activated during encoding and expression of a memory.

2014-07-04

Zebrafish as a new model for phenotype-based screening o...

The zebrafish-based assay is a widely used animal model system for cardiovascular research. In this study, we investigated the cardiac defects caused by terfenadine and tested the pharmacological response of digoxin to zebrafish with cardiac defects.

2014-07-04

Antinociceptive effects of buprenorphine in zebrafish la...

The underlying processes of nociception and pain are, despite the rodent models available, still not fully understood. One of the drawbacks of rodent model systems is the difficulty to screen compound libraries for their influence on nociception, thus slowing down the discovery of novel analgesics for clinical use.

2014-03-10

Discovery of a Natural Product-Like iNOS Inhibitor by Mo...

In this study, we applied structure-based virtual screening techniques to identify natural product or natural product-like inhibitors of iNOS.

2014-04-01

Applicability of the TCDD-TEQ approach to predict sublet...

Ecotoxicology with the ZebraBox

2014-02-18

Identification of compounds with anti-convulsant propert...

The availability of animal models of epileptic seizures provides opportunities to identify novel anticonvulsants for the treatment of people with epilepsy.

2012-11-01

Eriocaulon buergerianum extract protects PC12 cells and...

Eriocaulon buergerianum extract protects PC12 cells and neurons in zebrafish against 6-hydroxydopamine-induced damage

2011-06-06

Toxicity assessment of zebrafish following exposure...

Toxicity assessment of zebrafish following exposure to CdTe QDs

2012-02-14

Genomic and functional conservation of sedative-hypnotic...

Genomic and functional conservation of sedative-hypnotic targets in the zebrafish

2009-01-01

Interhemispheric asymmetry of olfactory input dependent...

Interhemispheric asymmetry of olfactory input dependent neuronal specification in the adult brain

2013-05-19

A high-throughput zebrafish screening method for visual...

Normal and visually-impaired zebrafish larvae have differentiable light-induced locomotor response (LLR), which is composed of visual and non-visual components

2014-08-09

Knockdown of Type 3 Iodothyronine Deiodinase Severely Pe...

Zebrafish care The Wild Indian Karyotype (WIK) strain of zebrafish was reared in community tanks on a 14-hour light, 10-hour dark cycle. Fish were fed twice a day, once with formulated feed (Dr. Bassleer Biofish Food) and once with Artemia larvae (cysts from Ocean Nutrition Europe). Eggs were collected 20 minutes after natural spawning and rinsed with system water to minimize infections. Embryos were raised at 28 ± 0.5°C in Danieau's medium. All animal experiments were approved by the Institutional Ethical Committee of the Katholieke Universiteit Leuven and executed in strict accordance with the European Council Directive (2010/63/EC).

2014-01-27

Linking genomic responses of gonads with reproductive im...

http://www.sciencedirect.com/science/article/pii/S0166445X16303794

2017-01-03

Vitamin E reduces endosulfan-induced toxic effects on mo...

http://www.sciencedirect.com/science/article/pii/S0278691517300042

2017-01-10

Use of the Zebrafish Larvae as a Model to Study Cigarett...

The link between tobacco use and the development of serious diseases such as certain cancers, heart disease, respiratory diseases and stroke are well established [1]. Despite this, tobacco use continues to be a growing global epidemic and remains the leading cause of preventable death worldwide [2]. More than 37,000 Canadians have been estimated to die prematurely on an annual basis as a consequence of tobacco smoking [3] and costs to the health care system are estimated at over $4.3 billion annually [4]. As such, tobacco use remains a public health concern in Canada.

2014-12-18

Cystinosis (ctns) zebrafish mutant shows pronephric glom...

Elmonem, M. A. et al. Cystinosis (ctns) zebrafish mutant shows pronephric glomerular and tubular dysfunction. Sci. Rep. 7, 42583; doi: 10.1038/srep42583 (2017).

2017-02-21

Functional analysis of the transmembrane and cytoplasmic...

http://www.jneurosci.org/content/early/2017/02/20/JNEUROSCI.2216-16.2017

2017-02-25

Measuring Larval Zebrafish Behavior: Locomotion, Thigmot...

Measuring Larval Zebrafish Behavior: Locomotion, Thigmotaxis, and StartleMeasuring Larval Zebrafish Behavior: Locomotion, Thigmotaxis, and Startle

2013-06-19

Effects of cadmium, manganese, and lead on locomotor act...

http://onlinelibrary.wiley.com/doi/10.1002/etc.3748/full

2017-01-28

Lipid quantitation and metabolomics data from vitamin E-...

http://www.sciencedirect.com/science/article/pii/S2352340917300653

2017-02-25

Lethal dysregulation of energy metabolism during embryon...

http://www.sciencedirect.com/science/article/pii/S0891584917300291

2017-01-21

A Small Organic Compound Mimicking the L1 Cell Adhesion...

http://link.springer.com/article/10.1007/s12035-016-0254-z

2017-01-14

Reversal of pentylenetetrazole-altered swimming and neur...

Extensive ethnopharmaceutical documentation is available on plants with demonstrated psychoactivity in humans (for review (Raetsch 2005)). Even though there is a huge need for new molecules in mental health, this reservoir of knowledge remains greatly untapped. One of the main reasons is probably the lack of a good in vivo system allowing testing of psychoactive efficacy of complex mixtures of unknown composition. Ethnobotanical reports on a specific plant often differ on plant species/subspecies/harvest but also on mode of preparation and administration which all generate a number of imponderable parameters. Therefore, it is necessary to establish a system which would be capable of circumventing those problems. Ideally, the proposed system has to be flexible and sensitive enough to allow rapid and systematic screening of a big number of complex mixtures like crude plants extracts. In such a system, first pass screening could be done with minimally processed extracts like preparations made from dried powdered parts of a plant of interest. Subsequently, gradually refined mixtures could be tested the same way to eventually isolate the active compound(s).

2011-01-01

TBBPA exposure during a sensitive developmental window p...

8–48 hpf is the sensitive exposure window for neurodevelopmental and behavioral toxicities of TBBPA. TBBPA induced apoptotic cell death and affected motor neuron and muscle fiber development. Zebrafish embryos rapidly absorbed and accumulated TBBPA, and eliminated it quickly. • TBBPA induced ugt genes expression, which increased T4 metabolism and subsequently induced neurobehavior defects.

2016-07-01

TBBPA chronic exposure produces sex-specific neurobehavi...

Low dose TBBPA chronic exposure reduced zebrafish body weight and length. TBBPA exposure induced adult zebrafish hyperactivity with magnitude bigger in males than in females. Low dose TBBPA exposure induced male zebrafish heightened aggression using mirror attack test.

2016-07-01

Effects of titanium dioxide nanoparticles exposure on pa...

http://www.sciencedirect.com/science/article/pii/S0045653517300735

2017-01-21

A novel method for automated tracking and quantification...

Highlights Custom-made economic imaging setup for distraction-free behavioural recording. ImageJ based algorithm for fast and automated tracking of Zebrafish without plugins. Mathematical workflow for extraction of behavioural endpoints. New representation for spatio-temporal nature of choice-based behaviours.

2011-01-01

Hormetic effect of panaxatriol saponins confers neuropro...

Zhang, C. et al. Hormetic effect of panaxatriol saponins confers neuroprotection in PC12 cells and zebrafish through PI3K/AKT/mTOR and AMPK/SIRT1/FOXO3 pathways. Sci. Rep. 7, 41082; doi: 10.1038/srep41082 (2017).

2017-01-23

Maternal cortisol stimulates neurogenesis and affects la...

Best, C. et al. Maternal cortisol stimulates neurogenesis and affects larval behaviour in zebrafish. Sci. Rep. 7, 40905; doi: 10.1038/srep40905 (2017).

2017-01-18

A New Statistical Approach to Characterize Chemical-Elic...

Zhang G, Truong L, Tanguay RL, Reif DM (2017) A New Statistical Approach to Characterize Chemical-Elicited Behavioral Effects in High-Throughput Studies Using Zebrafish. PLoS ONE 12(1): e0169408. doi:10.1371/journal.pone.0169408

2017-01-18

Surface Waters - places of invisible pollution -Movie

VU University in Amsterdam uses the Zebrabox technology to investigate the effect of micro-pollutants.

2013-06-01

Drug Screening to Treat Early-Onset Eye Diseases: Can Ze...

Drug Screening to Treat Early-Onset Eye Diseases: Can Zebrafish Expedite the Discovery?

2012-10-23

ZebraBox & ZebraLab Publication (more)

Hundreds of top universities and companies using the ZebraBox.

2013-06-20

A New Multi-cell Exposure System for Continuous T...

With recent advances in behavior tracking technology, we were able to develop a new behavioral analysis multi-cell exposure system named “Multi-DaphTrack” with a high-throughput testing capacity for assessing the behavioral response of Daphnia magna

2010-01-01

Hypocretin/Orexin Overexpression Induces An Insomnia-Lik...

Hypocretin/Orexin Overexpression Induces An Insomnia-Like Phenotype in Zebrafish

2010-12-20