Danger of environmental lead exposure to our health tested in Zebrafish
Published: 05-20-2019 In Publication
Zebrafish neurobehavioral phenomics applied as the behavioral warning methods forfingerprinting endocrine disrupting effect bylead exposure at environmentally relevant level
Researchers from the Shandong University, China, used the ZebraTower system as the biological early warning system (BEWS) to find that Pb exerted biphasic effects on the courtship behavior and endocrine regulation of male adult zebrafish.
Environmental lead (Pb) exposure is a great hazard to the public health. Although environmentallyrelevant Pb poisoning is preventable, insidious Pb contaminants are still a major threat to human health.Herein, we reported that exposure to Pb at environmentally relevant concentration level (1mg/L, 10mg/Land 100mg/L), disturbed the courtship behavior of adult male zebrafish and further altered the tran-scriptional patterns of key genes involved in testicular steroidogenesis (igf3, amh, piwil1, lhcgr, fshr,cyp11c1,star, cyp19a1a, cyp19a1b) and apoptosis (bax, cytoC, caspase 9, caspase 3, puma). Both thebehavioral and the transcriptional profiles share a similar biphasic dose response, with stimulatory ef-fects after low-level exposure and inhibitory effects after high-level exposure. This results revealed theendocrine disrupting effects of Pb even at an environmentally relevant level within the concentrationrange of ambient water quality criteria (AWQC) and the reliability of locomotionfingerprint as the in-dicator for detecting the risk induced by Pb pollution. Current research, for thefirst time, employed theZebraTower system as the biological early warning system (BEWS) tofind that Pb exerted biphasic effectson the courtship behavior and endocrine regulation of male adult zebrafish. Methodologically, wefirstlypropose an efficient solution to monitor and assess the risk of Pb exposure by combining the (BEWS) anddata analyzing methods such as zebrafish phenomics, which would make a contribution tothe detectionand prevention of environmentally relevant Pb poisoning.