Developmental neurotoxicity fingerprint of silica nanoparticles at environmentally relevant level on larval zebrafish using a neurobehavioral-phenomics-based biological warning method
Published: 08-21-2020 In Publication
Highlights
- • Silica NPs at environmental level induced the negligible embryonic teratogenicity.
- • Silica NPs at environmental level altered behavioral profiles determined by NBP.
- • NBP are more sensitive and effective than FET to determine sub-teratogenic toxicity.
Abstract
Background
Larval zebrafish (Danio rerio) is not only an ideal vertebrate applied in Fish Embryos Toxicity (FET) test but also a well-accepted model in behavioral neurotoxicity research. By applying the commercial standard behavioral tracking system (Zebrabox), the locomotion profiles (neurobehavioral-phenomics) of larval zebrafish can be comprehensively monitored and systematically analyzed to probe ecotoxicological neurotoxicity of nano-pollutants at environmental relevant concentration level.
Link to the publication :
https://www.sciencedirect.com/science/article/abs/pii/S0048969720354073