Genetic Risk Factors in prediction and treatment of Chronic Post-Surgical Pain

Concluding remarks :

This dissertation aimed to study the role of genetics in prediction and treatment of chronic postsurgical pain. In view of this, we started genetic screening and provided a genome-wide insight into the genetics of CPSP. This initial step identified the first potential risk loci and candidates for follow up studies. Furthermore, we have shown the important role of genetic variations related to dopaminergic neurotransmission in CPSP and preformed first steps in genetic and pharmacological screening in a zebrafish nociception model. With this dissertation a framework is provided for future studies and a combined and focussed clinical /pre-clinical approach aimed to develop personalized medicine in treatment of CPSP.


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