Selective activation of D1 dopamine receptors exerts antidepressant-like activity in rats

Published: 10-08-2020 In Publication

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Major depressive disorder is a common illness that severely decreases psychosocial functioning. Due to the major limitations of current treatments including response failure, it is crucial to develop better therapy strategies. Evidence suggests that dopamine dysregulation might play a major role in major depressive disorder physiopathology.

This study investigates whether the dopamine D1 receptor agonist A77636 modulates antidepressant-like activity in rats.


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