Investigate auditory responses and hearing loss in larval zebrafish

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points icon Use zebrafish as a model for auditory issues

As hearing deficiencies are said to increase in the coming years, assessing the hearing functions of larval zebrafish is critical to confront the issue of hearing loss.



Exploration of the zebrafish auditory apparatus led to the creation of automatic recording techniques monitoring specific behaviors such as the startle response, the vestibulo-ocular reflex, rheotaxis prepulse inhibition, or auditory evoked behavior.



To assess the general activity level of larval zebrafish exposed to a certain range of noises - or very fast behaviors (startle reflex, prepulse inhibition) - new automation capabilities were needed. Among them is the ability to synchronize the stimulus and the camera frames to allow the finest accuracy in measurement.



The high throughput monitoring of the Larval Zebrafish auditory system is of particular interest, especially when trying to model human hearing disorders and treat age-related hearing loss, Pendred syndrome, or other rare diseases such as Wolfram Syndrome. 

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HARDWARE PRODUCTS

points icon ZebraBox for analysis of embryos and larvae

hexagone Embryon
hexagone Larvae
ZebraBox

ZebraBox

Hardware
Locomotion monitoring with stimulation module
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ZebraFish

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Fish Behavior Monitoring

Fish Behavior Monitoring

Assess behavioral research in zebrafish such as social behavior, learning and memory, drug screening and much more...
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Assess behavioral research in zebrafish such as social behavior , learning and memory, drugs screening and much more...
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Learn from the consequences of actions with positive and negative reinforcements increasing the likelihood of the behavior being repeated